Article

Precise and programmable C:G to G:C base editing in genomic DNA

2020-07-21

Abstract excerpt

Many genetic diseases are caused by single-nucleotide polymorphisms (SNPs). Base editors can correct SNPs at single-nucleotide resolution, but until recently, only allowed for C:G to T:A and A:T to G:C transition edits, addressing four out of twelve possible DNA base substitutions. Here we developed a novel class of C:G to G:C Base Editors (CGBEs) to create single-base genomic transversions in human cells. Our CGB...

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Literature Corpus work: 609be2e2-622c-5621-bd7d-755b4529cd0c
DOI: 10.1101/2020.07.21.213827

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