Article

Ras Suppresses TXNIP Expression by Restricting Ribosome Translocation

2018-04-11

Abstract excerpt

<h4>ABSTRACT</h4> Oncogenic Ras upregulates aerobic glycolysis to meet the bioenergetic and biosynthetic demands of rapidly growing cells. In contrast, Thioredoxin interacting protein (TXNIP) is a potent inhibitor of glucose uptake and is frequently downregulated in human cancers. Our lab previously discovered that Ras activation suppresses TXNIP transcription and translation. In this report, we developed a syste...

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Literature Corpus work: 3a5956a5-4e55-5f09-8ac7-490d6fabed98
DOI: 10.1101/299354

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