Article

Protein synthesis inhibitors stimulate MondoA transcriptional activity by driving an accumulation of glucose 6-phosphate

2020-11-10

Abstract excerpt

<title>Abstract</title> <p><bold>BACKGROUND </bold>Protein synthesis is regulated by the availability of amino acids, the engagement of growth factor signaling pathways and ATP levels sufficient to support translation. Crosstalk between these inputs is extensive, yet other regulatory mechanisms remain to be characterized. For example, the translation initiation inhibitor Rocaglamide A (RocA) induces Thioredoxin I...

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Literature Corpus work: 361a7ce7-f762-566e-b798-c9692fc40e01
DOI: 10.21203/rs.3.rs-39919/v2

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