Article
Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.
The Journal of biological chemistry - 30 Mar 2018
Park Min Ju, Shen Hailian, Spaeth Jason M, Tolvanen Jaana H, Failor Courtney, Knudtson Jennifer F, McLaughlin Jessica, Halder Sunil K, Yang Qiwei, Bulun Serdar E, Al-Hendy Ayman, Schenken Robert S, Aaltonen Lauri A, Boyer Thomas G
Abstract excerpt
Somatic mutations in exon 2 of the RNA polymerase II transcriptional Mediator subunit MED12 occur at high frequency in uterine fibroids (UFs) and breast fibroepithelial tumors as well as recurrently, albeit less frequently, in malignant uterine leimyosarcomas, chronic lymphocytic leukemias, and colorectal cancers. Previously, we reported that UF-linked mutations in MED12 disrupt its ability to activate cyclin C...
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