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Article

CDK12: cellular functions and therapeutic potential of versatile player in cancer

1 Mar 2020

Abstract excerpt

Abstract Cyclin-dependent kinase 12 (CDK12) phosphorylates the C-terminal domain of RNA polymerase II and is needed for the optimal transcription elongation and translation of a subset of human protein-coding genes. The kinase has a pleiotropic effect on the maintenance of genome stability, and its inactivation in prostate and ovarian tumours results in focal tandem duplications, a CDK12-unique genome instability...

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PMID: 34316683
DOI: 10.1093/narcan/zcaa003

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