Article

Non-coding Regulatory Variants in ASD (Autism Spectrum Disorders) Disrupt CTCF Domains and Shape Cell-Type–Specific Neurodevelopmental Landscapes Revealed by Single-Cell Analyses and Cortical Organoids

2026-06-05

Abstract excerpt

<title>Abstract</title> <p>Background Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder with substantial genetic heterogeneity. While coding variants have been extensively studied, non-coding regulatory variants—which constitute approximately 99% of the human genome—remain largely underexplored. Their functional impact, particularly at the single-cell level and in organoid models, requires...

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Literature Corpus work: f65d11a1-3e11-5a83-8420-768761865f92
DOI: 10.21203/rs.3.rs-9650619/v1

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