Article
Allele-specific open chromatin in human iPSC neurons elucidates functional disease variants.
Science (New York, N.Y.) - 31 Jul 2020
Zhang Siwei, Zhang Hanwen, Zhou Yifan, Qiao Min, Zhao Siming, Kozlova Alena, Shi Jianxin, Sanders Alan R, Wang Gao, Luo Kaixuan, Sengupta Subhajit, West Siobhan, Qian Sheng, Streit Michael, Avramopoulos Dimitrios, Cowan Chad A, Chen Mengjie, Pang Zhiping P, Gejman Pablo V, He Xin, Duan Jubao
Abstract excerpt
Most neuropsychiatric disease risk variants are in noncoding sequences and lack functional interpretation. Because regulatory sequences often reside in open chromatin, we reasoned that neuropsychiatric disease risk variants may affect chromatin accessibility during neurodevelopment. Using human induced pluripotent stem cell (iPSC)-derived neurons that model developing brains, we identified thousands of genetic...
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