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Multi-omics approaches reveal that diffuse midline gliomas present altered DNA replication and are susceptible to replication stress therapy.

Genome biology - 20 Dec 2024

Hains Anastasia E, Chetal Kashish, Nakatani Tsunetoshi, Marques Joana G, Ettinger Andreas, Junior Carlos A O Biagi, Gonzalez-Sandoval Adriana, Pillai Renjitha, Filbin Mariella G, Torres-Padilla Maria-Elena, Sadreyev Ruslan I, Van Rechem Capucine

Abstract excerpt

BACKGROUND: The fatal diffuse midline gliomas (DMG) are characterized by an undruggable H3K27M mutation in H3.1 or H3.3. K27M impairs normal development by stalling differentiation. The identification of targetable pathways remains very poorly explored. Toward this goal, we undertake a multi-omics approach to evaluate replication timing profiles, transcriptomics, and cell cycle features in DMG cells from both...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39707510
DOI: 10.1186/s13059-024-03460-y
PMCID: PMC11660928

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