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Lactylation fuels nucleotide biosynthesis and facilitates deuterium metabolic imaging of tumor proliferation in H3K27M-mutant gliomas

2025-01-03

Abstract excerpt

<h4>ABSTRACT</h4> Oncogenes hyperactive lactate production, but the mechanisms by which lactate facilitates tumor growth are unclear. Here, we demonstrate that lactate is essential for nucleotide biosynthesis in pediatric diffuse midline gliomas (DMGs). The oncogenic histone H3K27M mutation upregulates phosphoglycerate kinase 1 (PGK1) and drives lactate production from [U- 13 C]-glucose in DMGs. Lactate activate...

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Literature Corpus work
6e9668a9-f2a9-5a2d-a0bf-fd289bed0296
DOI
10.1101/2025.01.02.631150
Open publication

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Lactylation fuels nucleotide biosynthesis and facilitates deuterium metabolic imaging of tumor proliferation in H3K27M-mutant gliomasDOI 10.1101/2025.01.02.631150
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