Article

Single-cell multi-omics analysis identifies metabolism-linked epigenetic reprogramming as a driver of therapy-resistant medulloblastoma

2024-12-13

Abstract excerpt

<title>Abstract</title> <p>Medulloblastoma (MB) is the most prevalent malignant brain tumor in children, exhibiting clinical and genomic heterogeneity. Of the four major subgroups, Group 3 tumors (MYC-MB), display high levels of MYC and metastasis rates. Despite treatment with surgery, radiation, and chemotherapy, patients with Group 3 MB are more likely to develop aggressive recurrent tumors with poor survival....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9d671291-0a25-550b-818a-b89802b2fbcb
DOI: 10.21203/rs.3.rs-5522707/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell multi-omics analysis identifies metabolism-linked epigenetic reprogramming as a driver of therapy-resistant medulloblastomaDOI 10.21203/rs.3.rs-5522707/v1Read

Deciphering Medulloblastoma: Epigenetic and Metabolic Changes Driving Tumorigenesis and Treatment OutcomesSemantic proximity Read

Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation.Semantic proximity Read

A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade gliomaSemantic proximity Read

Acquired genetic and cell-state changes in IDH-mutant glioma progression.Semantic proximity Read

Single-cell multimodal glioma analyses reveal epigenetic regulators of cellular plasticity and environmental stress responseSemantic proximity Read

Integrative multi-omics combined with functional pharmacological profiling in patient-derived organoids identifies personalized therapeutic vulnerabilities of adult high-grade gliomasSemantic proximity Read

Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response.Semantic proximity Read

Spatial pharmaco-multiomics reveals drug distribution, metabolic niches, and spatially constrained resistance in medulloblastomaSemantic proximity Read

Generation, characterization and drug sensitivities of twelve patient-derived IDH1 mutant glioma cell culturesSemantic proximity Read

Generation, characterization, and drug sensitivities of 12 patient-derived IDH1-mutant glioma cell culturesSemantic proximity Read

Group-specific cellular metabolism in Medulloblastoma.Semantic proximity Read

Multi-omics and Pharmacological Characterization of Patient-derived Glioma Cell LinesSemantic proximity Read