Article

Purine metabolism regulates DNA repair and therapy resistance in glioblastoma

2020-03-29

Abstract excerpt

Intratumoral genomic heterogeneity in glioblastoma (GBM) is a barrier to overcoming therapy resistance, and new strategies that are effective independent of genotype are urgently needed. By correlating intracellular metabolite levels with radiation resistance across dozens of genomically-distinct models of GBM, we found that purine metabolites strongly correlated with radiation resistance. Inhibiting purine, but n...

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Literature Corpus work: 9d2b17ce-4b7b-5a42-abe0-d7d3fee7906a
DOI: 10.1101/2020.03.26.010140

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