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Article

Targeting the reprogrammed metabolism in H3.3K27M pediatric high-grade gliomas.

Biochimica et biophysica acta. Molecular basis of disease - 1 Aug 2024

de Camargo Magalhães Eduardo S, de Bont Eveline S J M, Bruggeman Sophia W M, Lima Flavia R S

Abstract excerpt

Recent studies in Diffuse Midline Gliomas (DMG) demonstrated a strong connection between epigenome dysregulation and metabolic rewiring. Here, we evaluated the value of targeting a glycolytic protein named Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase 3 (PFKFB3) in H3.3K27M DMG. We observed that the viability of H3.3K27M cells is dramatically reduced by PFK15, a potent inhibitor of PFKFB3. Furthermore,...

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Identifiers

PMID: 38777100
DOI: 10.1016/j.bbadis.2024.167248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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