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Article

<i>PTCH1</i> mutant human cerebellar organoids are associated with altered neural development and early pathways of medulloblastoma oncogenesis

2023-05-10

Abstract excerpt

<h4>Summary</h4> Patched 1 (PTCH1) is the primary receptor for Sonic Hedgehog (SHH) ligand and negatively regulates SHH signalling, an essential pathway in human embryogenesis. Loss-of-function mutations in PTCH1 are associated with altered neuronal development and the malignant brain tumour medulloblastoma (MB). As a result of differences between murine and human development, molecular and cellular perturbation...

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Literature Corpus work
39a33afe-a9e1-5fb4-b415-d3e2b4f2fb46
DOI
10.1101/2023.05.10.540200
Open publication

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<i>PTCH1</i> mutant human cerebellar organoids are associated with altered neural development and early pathways of medulloblastoma oncogenesisDOI 10.1101/2023.05.10.540200
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