Article
Developmental and oncogenic effects of insulin-like growth factor-I in Ptc1+/- mouse cerebellum.
Molecular cancer - 9 Mar 2010
Tanori Mirella, Santone Melissa, Mancuso Mariateresa, Pasquali Emanuela, Leonardi Simona, Di Majo Vincenzo, Rebessi Simonetta, Saran Anna, Pazzaglia Simonetta
Abstract excerpt
BACKGROUND: Medulloblastoma is amongst the most common malignant brain tumors in childhood, arising from neoplastic transformation of granule neuron precursors (GNPs) of the cerebellum via deregulation of pathways involved in cerebellar development. Deregulation of the Sonic hedgehog/Patched1 (Shh/Ptc1) signaling pathway predisposes humans and mice to medulloblastoma. In the brain, insulin-like growth factor...
Topics
- Animals
- Apoptosis
- Cell Differentiation
- Cell Proliferation
- Cerebellum
- Humans
- Insulin-Like Growth Factor I
- Intermediate Filament Proteins
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutation
- Nerve Tissue Proteins