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A simple and scalable zebrafish model of Sonic hedgehog medulloblastoma

29 Jul 2024

Abstract excerpt

Medulloblastoma (MB) is the most common malignant brain tumor in children and is stratified into three major subgroups. The Sonic hedgehog (SHH) subgroup represents ∼30% of all MB cases and has significant survival disparity depending upon TP53 status. Here, we describe a zebrafish model of SHH MB using CRISPR to create mutant ptch1, the primary genetic driver of human SHH MB. In these animals, tumors rapidly...

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Glioma Diagnosis and Treatment
Hedgehog Signaling Pathway Studies
MicroRNA in disease regulation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39078737
DOI: 10.1016/j.celrep.2024.114559

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