Article

Childhood Cerebellar Tumors Mirror Conserved Fetal Transcriptional Programs

2018-06-19

Abstract excerpt

<h4>Summary</h4> The study of the origin and development of cerebellar tumours has been hampered by the complexity and heterogeneity of cerebellar cells that change over the course of development. We used single-cell transcriptomics to study >60,000 cells from the developing murine cerebellum, and show that different molecular subgroups of childhood cerebellar tumors mirror the transcription of cells from distinc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 88d27b7c-fb40-5314-8ac8-cb26edc1d25e
DOI: 10.1101/350280

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Childhood Cerebellar Tumors Mirror Conserved Fetal Transcriptional ProgramsDOI 10.1101/350280Read

Spatial and single-cell transcriptional landscape of human cerebellar developmentSemantic proximity Read

Mapping pediatric brain tumors to their origins in the developing cerebellumSemantic proximity Read

Mapping pediatric brain tumors to their origins in the developing cerebellumSemantic proximity Read

Integration of human and mouse single-cell transcriptomes of the developing cerebellum nominates cells-of-origin for Group 3 and 4 medulloblastomaSemantic proximity Read

Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesisSemantic proximity Read

Developmental Origins and Oncogenesis in MedulloblastomaSemantic proximity Read

Cerebellar stem cells act as medulloblastoma-initiating cells in a mouse model and a neural stem cell signature characterizes a subset of human medulloblastomasSemantic proximity Read

Cellular development and evolution of the mammalian cerebellumSemantic proximity Read

Cryptic developmental events determine medulloblastoma radiosensitivity and cellular heterogeneity without altering transcriptomic profile.Semantic proximity Read

Multimodal Validation of the Existence of Transitional Cerebellar Progenitors in the Human Fetal CerebellumSemantic proximity Read

Integrated single-cell transcriptomic and epigenetic analyses of cell-state transition and lineage commitment in the embryonic mouse cerebellumSemantic proximity Read

Oncogene aberrations drive medulloblastoma progression, not initiationSemantic proximity Read