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Article

Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma.

PloS one - 1 Jan 2015

Vaillant Catherine, Valdivieso Paola, Nuciforo Sandro, Kool Marcel, Schwarzentruber-Schauerte Alexandra, Méreau Hélène, Cabuy Erik, Lobrinus Johannes A, Pfister Stefan, Zuniga Aimée, Frank Stephan, Zeller Rolf

Abstract excerpt

BACKGROUND: Medulloblastomas are malignant childhood brain tumors that arise due to the aberrant activity of developmental pathways during postnatal cerebellar development and in adult humans. Transcriptome analysis has identified four major medulloblastoma subgroups. One of them, the Sonic hedgehog (SHH) subgroup, is caused by aberrant Hedgehog signal transduction due to mutations in the Patched1 (PTCH1)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25901736
DOI: 10.1371/journal.pone.0124870
PMCID: PMC4406471

Genes

SHH
SERPINE2
PTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma.PMID 25901736Read ↗

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