Article

A Simple and Scalable Zebrafish Model of Sonic Hedgehog Medulloblastoma

2024-02-05

Abstract excerpt

<h4>Summary</h4> Medulloblastoma (MB) is the most common malignant brain tumor in children and is stratified into three major subgroups. The Sonic hedgehog (SHH) subgroup represents ∼30% of all MB cases and has significant survival disparity depending upon TP53 status. Here, we describe the first zebrafish model of SHH MB using CRISPR to mutate ptch1 , the primary genetic driver in human SHH MB. These tumors rap...

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Literature Corpus work: 2bb8aba3-5176-5100-b298-590ffef61f26
DOI: 10.1101/2024.02.03.577834

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