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Sonic hedgehog medulloblastoma cells in co-culture with cerebellar organoids converge towards <i>in vivo</i> malignant cell states

2024-04-02

Abstract excerpt

<h4>Background</h4> In the malignant brain tumour sonic hedgehog medulloblastoma (SHH-MB) the properties of cancer cells are influenced by their microenvironment, but the nature of those effects and the phenotypic consequences for the tumour are poorly understood. The aim of this study was to identify phenotypic properties of SHH-MB cells that were driven by the non-malignant tumour microenvironment. <h4>Methods<...

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Literature Corpus work
72f70ebe-387a-5000-a731-16e630e19808
DOI
10.1101/2024.04.01.587603
Open publication

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Sonic hedgehog medulloblastoma cells in co-culture with cerebellar organoids converge towards <i>in vivo</i> malignant cell statesDOI 10.1101/2024.04.01.587603
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