Article
Pik3ca mutations significantly enhance the growth of SHH medulloblastoma and lead to metastatic tumour growth in a novel mouse model.
Cancer letters - 1 May 2020
Niesen Judith, Ohli Jasmin, Sedlacik Jan, Dührsen Lasse, Hellwig Malte, Spohn Michael, Holsten Till, Schüller Ulrich
Abstract excerpt
Medulloblastoma (MB) is the most frequent malignant brain tumour in children with a poor outcome. Divided into four molecular subgroups, MB of the Sonic hedgehog (SHH) subgroup accounts for approximately 25% of the cases and is driven by mutations within components of the SHH pathway, such as its receptors PTCH1 or SMO. A fraction of these cases additionally harbour PIK3CA mutations, the relevance of which is so...
Topics
- Animals
- Cerebellar Neoplasms
- Class I Phosphatidylinositol 3-Kinases
- Disease Models, Animal
- Hedgehog Proteins
- Humans
- Medulloblastoma
- Mice, Transgenic
- Mutation
- Neoplasms, Experimental