Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma.

Development (Cambridge, England) - 1 May 2005

Oliver Trudy G, Read Tracy Ann, Kessler Jessica D, Mehmeti Anriada, Wells Jonathan F, Huynh Trang T T, Lin Simon M, Wechsler-Reya Robert J

Abstract excerpt

Medulloblastoma is the most common malignant brain tumor in children. It is thought to result from the transformation of granule cell precursors (GCPs) in the developing cerebellum, but little is known about the early stages of the disease. Here, we identify a pre-neoplastic stage of medulloblastoma in patched heterozygous mice, a model of the human disease. We show that pre-neoplastic cells are present in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cerebellar Neoplasms
Share to Cerebellum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescent Antibody Technique

Share to Histological Techniques

Share to Medulloblastoma

Share to Microarray Analysis

Share to Patched Receptors

Share to Precancerous Conditions

Source

Identifiers

PMID: 15843415
DOI: 10.1242/dev.01793

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma.PMID 15843415Read ↗

Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice.Semantic proximity Read ↗

Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells.Semantic proximity Read ↗

<i>Insulin-like Growth Factor 2</i> Is Required for Progression to Advanced Medulloblastoma in <i>patched1</i> Heterozygous MiceSemantic proximity Read ↗

The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched.Semantic proximity Read ↗

Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma.Semantic proximity Read ↗

Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors.Semantic proximity Read ↗

Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched.Semantic proximity Read ↗

Two tumor suppressors, p27Kip1 and patched-1, collaborate to prevent medulloblastoma.Semantic proximity Read ↗

<i>PTCH1</i> mutant human cerebellar organoids are associated with altered neural development and early pathways of medulloblastoma oncogenesisSemantic proximity Read ↗

Thickened area of external granular layer and Ki-67 positive focus are early events of medulloblastoma in Ptch1⁺/⁻ mice.Semantic proximity Read ↗

The patched signaling pathway in tumorigenesis and development: lessons from animal models.Semantic proximity Read ↗

Tis21 knock-out enhances the frequency of medulloblastoma in Patched1 heterozygous mice by inhibiting the Cxcl3-dependent migration of cerebellar neurons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.