Article

The developmental stage of the medulloblastoma cell-of-origin restricts Hedgehog pathway usage and drug sensitivity

2021-01-22

Abstract excerpt

<h4>Summary</h4> Sonic Hedgehog (SHH) medulloblastoma originates from the cerebellar granule neuron progenitor (CGNP) lineage that depends on Hedgehog signaling for its perinatal expansion. While SHH tumors exhibit overall deregulation of this pathway, they also show patient age-specific aberrations. To investigate if the developmental stage of the CGNP can account for these age-specific lesions, we analyzed deve...

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Literature Corpus work: c3316c56-64f8-564b-9412-60423918df03
DOI: 10.1101/2021.01.22.427790

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