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Article

Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice.

Developmental biology - 1 Nov 2003

Kim John Y H, Nelson Aaron L, Algon Sibel A, Graves Ondrea, Sturla Lisa Marie, Goumnerova Liliana C, Rowitch David H, Segal Rosalind A, Pomeroy Scott L

Abstract excerpt

Medulloblastoma is a cerebellar tumor that can arise through aberrant activation of Sonic hedgehog (Shh) signaling, which normally regulates cerebellar granule cell proliferation. Mutations of the Shh receptor PATCHED (PTCH) are associated with medulloblastomas, which have not been found to have...

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Identifiers

PMID: 14568546
DOI: 10.1016/s0012-1606(03)00434-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14568546-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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