Article

HOPS: a quantitative score reveals pervasive horizontal pleiotropy in human genetic variation is driven by extreme polygenicity of human traits and diseases

2018-04-30

Abstract excerpt

Horizontal pleiotropy, where one variant has independent effects on multiple traits, is important for our understanding of the genetic architecture of human phenotypes. We develop a method to quantify horizontal pleiotropy using genome-wide association summary statistics and apply it to 372 heritable phenotypes measured in 361,194 UK Biobank individuals. Horizontal pleiotropy is pervasive throughout the human geno...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 396eecb0-c1a6-527b-a1e8-1c4cc290cae0
DOI: 10.1101/311332

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HOPS: a quantitative score reveals pervasive horizontal pleiotropy in human genetic variation is driven by extreme polygenicity of human traits and diseasesDOI 10.1101/311332Read

HOPS: a quantitative score reveals pervasive horizontal pleiotropy in human genetic variation is driven by extreme polygenicity of human traits and diseases.Semantic proximity Read

Inferring genetic variant networks by leveraging pleiotropy shows trait relationships drive massive pleiotropy in GWASSemantic proximity Read

Dissecting pleiotropy to gain mechanistic insights into human disease.Semantic proximity Read

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases.Semantic proximity Read

Joint Modeling of Effect Sizes for Two Correlated Traits: Characterizing Trait Properties to Enhance Polygenic Risk PredictionSemantic proximity Read

A global overview of pleiotropy and genetic architecture in complex traitsSemantic proximity Read

Pleiotropic heritability quantifies the shared genetic variance of common diseasesSemantic proximity Read

Building The Human Genotype-Phenotype Map to Harness Pleiotropy and Refine Disease MechanismsSemantic proximity Read

The Combined Analysis of Pleiotropy and Epistasis (CAPE).Semantic proximity Read

Joint modeling of effect sizes for two correlated traits: Characterizing trait properties to enhance polygenic risk prediction.Semantic proximity Read

Testing and controlling for horizontal pleiotropy with the probabilistic Mendelian randomization in transcriptome-wide association studiesSemantic proximity Read

Pleiotropic shared heritability quantifies the shared genetic variance of common diseases.Semantic proximity Read