Article
The Combined Analysis of Pleiotropy and Epistasis (CAPE).
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021
Tyler Anna L, Emerson Jake, El Kassaby Baha, Wells Ann E, Philip Vivek M, Carter Gregory W
Abstract excerpt
Epistasis, or gene-gene interaction, contributes substantially to trait variation in organisms ranging from yeast to humans, and modeling epistasis directly is critical to understanding the genotype-phenotype map. However, inference of genetic interactions is challenging compared to inference of individual allele effects due to low statistical power. Furthermore, genetic interactions can appear inconsistent...
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