Article

MTMR regulates KRAS function by controlling plasma membrane levels of phospholipids

2024-01-23

Abstract excerpt

KRAS, a small GTPase involved in cell proliferation and differentiation, frequently gains activating mutations in human cancers. For KRAS to function, it must bind the plasma membrane (PM) via interactions between its membrane anchor and phosphatidylserine (PtdSer). Therefore, depleting PM PtdSer abrogates KRAS PM binding and activity. From a genome-wide siRNA screen to identify genes regulating KRAS PM localizati...

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Literature Corpus work: 3963bb93-94c3-5b17-9b25-c4e182b74a8a
DOI: 10.1101/2024.01.22.576612

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