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Article

Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases.

Current biology : CB - 18 Mar 2003

Schaletzky Julia, Dove Stephen K, Short Benjamin, Lorenzo Oscar, Clague Michael J, Barr Francis A

Abstract excerpt

Phosphoinositides control many different processes required for normal cellular function. Myotubularins are a family of Phosphatidylinositol 3-phosphate (PtdIns3P) phosphatases identified by the positional cloning of the MTM1 gene in patients suffering from X-linked myotubular myopathy and the MTMR2 gene in patients suffering from the demyelinating neuropathy Charcot-Marie-Tooth disease type 4B. MTM1 is a...

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Source

Identifiers

PMID: 12646134
DOI: 10.1016/s0960-9822(03)00132-5

Genes

MTM1
MTMR2
MTMR3
MTMR6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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