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Article

Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth.

Nature communications - 5 Jun 2020

Sawade Linda, Grandi Federica, Mignanelli Marianna, Patiño-López Genaro, Klinkert Kerstin, Langa-Vives Francina, Di Guardo Roberta, Echard Arnaud, Bolino Alessandra, Haucke Volker

Abstract excerpt

Inherited peripheral neuropathies (IPNs) represent a broad group of disorders including Charcot-Marie-Tooth (CMT) neuropathies characterized by defects primarily arising in myelin, axons, or both. The molecular mechanisms by which mutations in nearly 100 identified IPN/CMT genes lead to neuropathies are poorly understood. Here we show that the Ras-related GTPase Rab35 controls myelin growth via complex formation...

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Identifiers

PMID: 32503983
DOI: 10.1038/s41467-020-16696-6
PMCID: PMC7275063

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