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Article

PLEKHA7 signaling is necessary for the growth of mutant KRAS driven colorectal cancer.

Experimental cell research - 15 Dec 2021

Jeung Hei-Cheul, Puentes Roisin, Aleshin Alexander, Indarte Martin, Correa Ricardo G, Bankston Laurie A, Layng Fabiana I A L, Ahmed Zamal, Wistuba Ignacio, Yao Yong, Duenas Daniela G, Zhang Shuxing, Meuillet Emmanuelle J, Marassi Francesca, Liddington Robert C, Kirkpatrick Lynn, Powis Garth

Abstract excerpt

Plekha7 (Pleckstrin homology [PH] domain containing, family A member 7) regulates the assembly of proteins of the cytoplasmic apical zonula adherens junction (AJ), thus ensuring cell-cell adhesion and tight-junction barrier integrity. Little is known of Plekha7 function in cancer. In colorectal cancer (CRC) Plekha7 expression is elevated compared to adjacent normal tissue levels, increasing with clinical stage....

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Identifiers

PMID: 34800542
DOI: 10.1016/j.yexcr.2021.112930
PMCID: PMC8925131

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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