Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RAS Function in cancer cells: translating membrane biology and biochemistry into new therapeutics.

The Biochemical journal - 14 Aug 2020

Kattan Walaa E, Hancock John F

Abstract excerpt

The three human RAS proteins are mutated and constitutively activated in ∼20% of cancers leading to cell growth and proliferation. For the past three decades, many attempts have been made to inhibit these proteins with little success. Recently; however, multiple methods have emerged to inhibit KRAS, the most prevalently mutated isoform. These methods and the underlying biology will be discussed in this review...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Cell Membrane
Share to Molecular Targeted Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms

Share to Protein Isoforms

Share to Protein Processing, Post-Translational

Share to Proto-Oncogene Proteins p21(ras)

Share to ras Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 32797215
DOI: 10.1042/BCJ20190839
PMCID: PMC7891675

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RAS Function in cancer cells: translating membrane biology and biochemistry into new therapeutics.PMID 32797215Read ↗

The Endeavours in RAS Inhibition - the Past, Present, and Future.Semantic proximity Read ↗

KRAS: From undruggable to a druggable Cancer Target.Semantic proximity Read ↗

Inhibition of Ras for cancer treatment: the search continues.Semantic proximity Read ↗

Progress in Targeting KRAS Directly.Semantic proximity Read ↗

The current state of the art and future trends in RAS-targeted cancer therapies.Semantic proximity Read ↗

Past, Present, and Future of Targeting Ras for Cancer Therapies.Semantic proximity Read ↗

Targeting K-Ras Mutations Show Promise Towards Ending Ras's "Undruggable" Era.Semantic proximity Read ↗

RAS signaling in carcinogenesis, cancer therapy and resistance mechanisms.Semantic proximity Read ↗

RAS, wanted dead or alive: Advances in targeting RAS mutant cancers.Semantic proximity Read ↗

Emerging RAS-directed therapies for cancerSemantic proximity Read ↗

Biology, pathology, and therapeutic targeting of RAS.Semantic proximity Read ↗

Small-Molecule RAS Inhibitors as Anticancer Agents: Discovery, Development, and Mechanistic Studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.