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Article

KRAS G12C and KRAS G12D respond to lipid metabolism in an allele-specific manner.

Journal of lipid research - 1 Jul 2026

Arora Neha, Liang Hong, Kattan Walaa, Yao Wantong, Ying Haoqiang, Liu Junchen, Zhou Yong

Abstract excerpt

KRAS mutated at hotspots G12, G13, and Q61 possess profound allele-specific oncogenesis. Signaling of KRAS mutants is mostly compartmentalized to the proteolipid nanoclusters on the plasma membrane (PM), illustrating critical roles of spatiotemporal organization in KRAS cancer signaling. The activated GTP-bound KRAS molecules, including the wild type and mutants, have been traditionally thought to favor similar...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42303154
DOI: 10.1016/j.jlr.2026.101079
PMCID: PMC13375922

Genes

KRAS
LPCAT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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