Article
The PTEN and Myotubularin phosphoinositide 3-phosphatases: linking lipid signalling to human disease.
Sub-cellular biochemistry - 1 Jan 2012
Davies Elizabeth M, Sheffield David A, Tibarewal Priyanka, Fedele Clare G, Mitchell Christina A, Leslie Nicholas R
Abstract excerpt
Two classes of lipid phosphatases selectively dephosphorylate the 3 position of the inositol ring of phosphoinositide signaling molecules: the PTEN and the Myotubularin families. PTEN dephosphorylates PtdIns(3,4,5)P(3), acting in direct opposition to the Class I PI3K enzymes in the regulation of cell growth, proliferation and polarity and is an important tumor suppressor. Although there are several PTEN-related...
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