Article

DHHC7 palmitoylates KRAS4A and promotes mutant KRAS-driven pancreatic cancers

2026-04-02

Abstract excerpt

KRAS mutations underlie many human cancers. While inhibitors such as Sotorasib and Adagrasib targeting KRAS mutants have shown promise, additional strategies are required to address the broader spectrum of KRAS-driven cancers, particularly those displaying drug resistance. Thus, there is a need to better understand KRAS signaling and develop new therapeutic strategies. Here we show that KRAS4A is palmitoylated on...

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Literature Corpus work: 6828aed2-9e01-5740-9f2e-a58c23c2470d
DOI: 10.64898/2026.03.31.715686

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