Article

Nanoclustering and signaling of KRAS G12C and KRAS G12D respond to lipid acyl chain remodeling in an allele-specific manner

2024-06-02

Abstract excerpt

Small GTPase KRAS mutated at hotspots, such as G12, G13 and Q61, are major drivers of cancer and display allele-specific oncogenic properties, which are not well understood. KRAS mutants require precise spatiotemporal distribution to the proteolipid nanoclusters on the plasma membrane (PM) for efficient signaling. We recently reported allele-specific lipid sensing of KRAS mutants. KRAS G12D , KRAS G12V and KRAS...

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Literature Corpus work: fa5b888f-d099-50fc-9f60-6845191f0b52
DOI: 10.1101/2024.05.30.596653

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