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Article

PTPN2 regulates the activation of KRAS and plays a critical role in proliferation and survival of KRAS-driven cancer cells.

The Journal of biological chemistry - 25 Dec 2020

Huang Zhangsen, Liu Mingzhu, Li Donghe, Tan Yun, Zhang Ruihong, Xia Zhizhou, Wang Peihong, Jiao Bo, Liu Ping, Ren Ruibao

Abstract excerpt

RAS genes are the most commonly mutated in human cancers and play critical roles in tumor initiation, progression, and drug resistance. Identification of targets that block RAS signaling is pivotal to develop therapies for RAS-related cancer. As RAS translocation to the plasma membrane (PM) is essential for its effective signal transduction, we devised a high-content screening assay to search for genes regulating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 2

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Source

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Identifiers

PMID: 33122197
DOI: 10.1074/jbc.RA119.011060
PMCID: PMC7939389

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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