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Article

The G protein-coupled receptor GPR31 promotes membrane association of KRAS.

The Journal of cell biology - 7 Aug 2017

Fehrenbacher Nicole, Tojal da Silva Israel, Ramirez Craig, Zhou Yong, Cho Kwang-Jin, Kuchay Shafi, Shi Jie, Thomas Susan, Pagano Michele, Hancock John F, Bar-Sagi Dafna, Philips Mark R

Abstract excerpt

The product of the KRAS oncogene, KRAS4B, promotes tumor growth when associated with the plasma membrane (PM). PM association is mediated, in part, by farnesylation of KRAS4B, but trafficking of nascent KRAS4B to the PM is incompletely understood. We performed a genome-wide screen to identify genes required for KRAS4B membrane association and identified a G protein-coupled receptor, GPR31. GPR31 associated with...

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Identifiers

PMID: 28619714
DOI: 10.1083/jcb.201609096
PMCID: PMC5551702

Genes

GPR31
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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