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A transgene-free, human peri-gastrulation embryo model with trilaminar embryonic disc-, amnion- and yolk sac-like structures

2024-08-07

Abstract excerpt

The ultimate outcome of the gastrulation in mammalian development is a recognizable trilaminar disc structure containing organized cell lineages with spatially defined identities in an emerging coordinate system 1–4 . Despite its importance in human development, gastrulation remains difficult to study. Stem cell-based embryo models, including those that recapitulate different aspects of pre- and peri-gastrulation...

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Literature Corpus work
3ff30615-49a8-5b3a-ba64-9a7e79ca1fbd
DOI
10.1101/2024.08.05.606556
Open publication

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