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Post-gastrulation amnioids as a stem cell-derived model of human extra-embryonic development

15 May 2025

Abstract excerpt

The amnion, an extra-embryonic tissue in mammalian embryos, is thought to provide crucial signaling, structural, and nutritional support during pregnancy. Despite its pivotal importance, studying human amnion formation and function has been hampered by the lack of accurate in vitro models. Here, we present an embryonic stem cell-derived 3D model of the post-gastrulation amnion, post-gastrulation amnioids (PGAs),...

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PMID: 40378847
DOI: 10.1016/j.cell.2025.04.025

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