LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease.

Abstract excerpt

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are found in familial and idiopathic cases of Parkinson's disease (PD), but are also associated with immune-related disorders, notably Crohn's disease and leprosy. Although the physiological function of LRRK2 protein remains largely elusive, increasing evidence suggests that it plays a role in innate immunity, a process that also has been implicated in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Central Nervous System
• Share to Immunity, Innate
• Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2