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Pan‐cancer proteogenomic landscape of whole‐genome doubling reveals putative therapeutic targets in various cancer types

1 Aug 2024

Abstract excerpt

Dear Editor, Whole-genome doubling (WGD) occurs in various cancer types and plays a crucial role in tumour development and genomic instability.1, 2 However, the proteogenomic characteristics and molecular regulators governing WGD have yet to be elucidated. By integrating large-scale multi-omics data from the Clinical Proteomic Tumor Analysis Consortium (CPTAC),3 we classified three types of WGD tumours across...

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PMID: 39148143
DOI: 10.1002/ctm2.1796

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