Article
Integrative proteogenomic characterization of hepatocellular carcinoma across etiologies and stages.
Nature communications - 4 May 2022
Ng Charlotte K Y, Dazert Eva, Boldanova Tuyana, Coto-Llerena Mairene, Nuciforo Sandro, Ercan Caner, Suslov Aleksei, Meier Marie-Anne, Bock Thomas, Schmidt Alexander, Ketterer Sylvia, Wang Xueya, Wieland Stefan, Matter Matthias S, Colombi Marco, Piscuoglio Salvatore, Terracciano Luigi M, Hall Michael N, Heim Markus H
Abstract excerpt
Proteogenomic analyses of hepatocellular carcinomas (HCC) have focused on early-stage, HBV-associated HCCs. Here we present an integrated proteogenomic analysis of HCCs across clinical stages and etiologies. Pathways related to cell cycle, transcriptional and translational control, signaling transduction, and metabolism are dysregulated and differentially regulated on the genomic, transcriptomic, proteomic and...
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