Article

Evolutionarily guided transcription factor design programs novel T cell states

2024-11-08

Abstract excerpt

Protein-coding genes in the human genome evolved via modular rearrangement of domains from ancestral genes 1 . Here, we develop a scalable, evolutionarily guided method to assemble novel protein-coding genes from constituent domains within a protein family, termed DESynR (Domain Engineered via Synthesis and Recombination) genes. Using primary human chimeric antigen receptor T cells as a model system, we find that...

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Literature Corpus work: 38ce72f8-1ae7-5d88-82c1-d133f8aac41e
DOI: 10.1101/2024.11.06.622344

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