Article

PETRA: Prime editing of transcribed regulatory elements to assay expression

2025-11-18

Abstract excerpt

<h4>ABSTRACT</h4> Predicting how changes in human DNA sequence impact gene expression remains challenging. Here, we present PETRA ( P rime E diting of T ranscribed R egulatory elements to A ssay expression), a multiplexed genome editing method to quantify the effects of regulatory variants at scale. PETRA leverages the delivery of variants to abundantly transcribed regions of genes such that sequence-specifi...

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Literature Corpus work: fa36dc47-2068-5f04-be63-f8c3771a51f9
DOI: 10.1101/2025.11.18.689114

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