Article
Direct and Indirect Effects of Maternal, Paternal, and Offspring Genotypes: Trio-GCTA.
Behavior genetics - 1 Mar 2021
Eilertsen Espen Moen, Jami Eshim Shahid, McAdams Tom A, Hannigan Laurie J, Havdahl Alexandra S, Magnus Per, Evans David M, Ystrom Eivind
Abstract excerpt
Indirect genetic effects from relatives may result in misleading quantifications of heritability, but can also be of interest in their own right. In this paper we propose Trio-GCTA, a model for separating direct and indirect genetic effects when genome-wide single nucleotide polymorphism data have been collected from parent-offspring trios. The model is applicable to phenotypes obtained from any of the family...
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