Article
Parent-of-Origin inference for biobanks.
Nature communications - 5 Nov 2022
Hofmeister Robin J, Rubinacci Simone, Ribeiro Diogo M, Buil Alfonso, Kutalik Zoltán, Delaneau Olivier
Abstract excerpt
Identical genetic variations can have different phenotypic effects depending on their parent of origin. Yet, studies focusing on parent-of-origin effects have been limited in terms of sample size due to the lack of parental genomes or known genealogies. We propose a probabilistic approach to infer the parent-of-origin of individual alleles that does not require parental genomes nor prior knowledge of genealogy....
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