Review of statistical methodologies for the detection of parent-of-origin effects in family trio genome-wide association data with binary disease traits.

Abstract excerpt

The detection of parent-of-origin effects aims to identify whether the functionality of alleles, and in turn associated phenotypic traits, depends on the parental origin of the alleles. Different parent-of-origin effects have been identified through a variety of mechanisms and a number of statistical methodologies for their detection have been proposed, in particular for genome-wide association studies (GWAS)....

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