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Article

Separating direct, indirect, and parent-of-origin genetic effects in the human population.

Cell genomics - 8 Jul 2026

Krätschmer Ilse, Hegemann Laura, Hofmeister Robin J, Corfield Elizabeth C, Mahmoudi Mahdi, Delaneau Olivier, Andreassen Ole A, Campbell Archie, Hayward Caroline, Marioni Riccardo E, Ystrom Eivind, Havdahl Alexandra, Robinson Matthew R

Abstract excerpt

We introduce JODIE, a genetic joint modeling approach that estimates how DNA loci influence human traits by partitioning genetic effects into four components: direct effects (from a child's alleles), indirect maternal and paternal effects (from parents' alleles), and parent-of-origin (PofO) effects (dependent on parental transmission of alleles), while uniquely accounting for assortative mating. We analyze 30,000...

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Identifiers

PMID: 42263682
DOI: 10.1016/j.xgen.2026.101277
PMCID: PMC13347940

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