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Article

POIROT: a powerful test for parent-of-origin effects in unrelated samples leveraging multiple phenotypes.

Bioinformatics (Oxford, England) - 3 Apr 2023

Head S Taylor, Leslie Elizabeth J, Cutler David J, Epstein Michael P

Abstract excerpt

MOTIVATION: There is widespread interest in identifying genetic variants that exhibit parent-of-origin effects (POEs) wherein the effect of an allele on phenotype expression depends on its parental origin. POEs can arise from different phenomena including genomic imprinting and have been documented for many complex traits. Traditional tests for POEs require family data to determine parental origins of transmitted...

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Identifiers

PMID: 37067493
DOI: 10.1093/bioinformatics/btad199
PMCID: PMC10148680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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