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Article

Parent-of-origin effects on complex traits in up to 236,781 individuals.

Nature - 1 Oct 2025

Hofmeister Robin J, Cavinato Théo, Karimi Roya, van der Graaf Adriaan, Pajuste Fanny-Dhelia, Kronberg Jaanika, Taba Nele, Mägi Reedik, Vaudel Marc, Rubinacci Simone, Johansson Stefan, Milani Lili, Delaneau Olivier, Kutalik Zoltán

Abstract excerpt

Parent-of-origin effects (POEs) occur when the effect of a genetic variant depends on its parental origin1. Traditionally linked to genomic imprinting, POEs are believed to occur due to parental conflict over resource allocation to offspring, resulting in opposing parental influences2. Despite their importance, POEs remain underexplored in complex traits, owing to the lack of parental genomes. Here we present an...

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Identifiers

PMID: 40770099
DOI: 10.1038/s41586-025-09357-5
PMCID: PMC12527933

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IGF1

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