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Article

Transactivation of programmed ribosomal frameshifting by a viral protein

13 May 2014

Abstract excerpt

Programmed -1 ribosomal frameshifting (-1 PRF) is a widely used translational mechanism facilitating the expression of two polypeptides from a single mRNA. Commonly, the ribosome interacts with an mRNA secondary structure that promotes -1 frameshifting on a homopolymeric slippery sequence. Recently, we described an unusual -2 frameshifting (-2 PRF) signal directing efficient expression of a transframe protein...

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PMID: 24825891
DOI: 10.1073/pnas.1321930111

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